WO2023238065 - NITROGEN CONTAINING CONDENSED 2,3-DIHYDROQUINAZOLINONE COMPOUNDS AS NAV1.8 INHIBITORS
National phase entry:
Publication Number
WO/2023/238065
Publication Date
14.12.2023
International Application No.
PCT/IB2023/055889
International Filing Date
07.06.2023
Title **
[English]
NITROGEN CONTAINING CONDENSED 2,3-DIHYDROQUINAZOLINONE COMPOUNDS AS NAV1.8 INHIBITORS
[French]
COMPOSÉS DE 2,3-DIHYDROQUINAZOLINONE CONDENSÉS CONTENANT DE L'AZOTE UTILISÉS EN TANT QU'INHIBITEURS DE NAV1.8
Applicants **
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
Inventors
GUANG, Jie
HO, Ming-Hsun
MATTHEWS, Jay M.
PRICE, Alan T.
SANCHEZ, Robert
SPLETSTOSER, Jared Troy
WASHBURN, David Glenn
BIERSCHENK, Stephen Marion
DAVIS, Roderick S.
FARMER, Marcus
LI, Mei
LIAO, Xiangmin
ROMANO, Joseph J.
SCHULZ, Mark J.
Priority Data
63/350,624
09.06.2022
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| Number of Office Actions | * |
| * | |
International Searching Authority |
EPO
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Patent Delivery |
Send the Letters Patent by Courier
* |
| Translation |
|
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 9951 | |
| EPO | Filing, Examination, Granting | 32246 | |
| Japan | Filing, Examination, Granting | 2471 | |
| South Korea | Filing, Examination, Granting | 2677 | |
| USA | Filing, Examination, Granting | 12340 |
Total:
59,685
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Contact Us
Abstract[English]
Small molecule inhibitors of Nav1.8 voltage-gated sodium ion channel, including compounds of formula (I), (II), (III), (IV), and (V) are described. Also described are pharmaceutical compositions containing a compound of formula (I), (II), (III), (IV), and (V) and uses of the compounds and pharmaceutical compositions for inhibiting Nav1.8 voltage-gated sodium channels and treating Nav1.8 mediated diseases, such as pain and pain-associated diseases and cardiovascular diseases, such as atrial fibrillation.[French]
L'invention concerne des inhibiteurs à petites molécules du canal ionique sodique voltage-dépendants Nav1.8, y compris des composés de formule (I), (II), (III), (IV) et (V). L'invention concerne également des compositions pharmaceutiques contenant un composé de formule (I), (II), (III), (IV) et (V) et des utilisations des composés et des compositions pharmaceutiques pour inhiber les canaux sodiques voltage-dépendants Nav1.8 et traiter des maladies médiées par Nav1.8, telles que la douleur et les maladies associées à la douleur et les maladies cardiovasculaires, telles que la fibrillation auriculaire.