WO2023139477 - PROMOTER FOR THE EXPRESSION OF GENES IN PARTICULAR CNR1-POSITIVE CELLS IN MOUSE CORTEX

National phase entry:
Publication Number WO/2023/139477
Publication Date 27.07.2023
International Application No. PCT/IB2023/050391
International Filing Date 17.01.2023
Title **
[English] PROMOTER FOR THE EXPRESSION OF GENES IN PARTICULAR CNR1-POSITIVE CELLS IN MOUSE CORTEX
[French] PROMOTEUR POUR L'EXPRESSION DE GÈNES DANS DES CELLULES CNR1-POSITIVES PARTICULIÈRES DANS LE CORTEX DE SOURIS
Applicants **
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
Inventors
KELLER, Georg
OYIBO, Hassana
Priority Data
22152307.9   19.01.2022   EP
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting1908
EPO Filing, Examination, Granting8163
Japan Filing, Examination, Granting2047
South Korea Filing, Examination, Granting1809
USA Filing, Examination, Granting7140
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Total: 21,067

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Abstract[English] The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1, or of a nucleic acid sequence of at least 1400 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule leads to the specific expression in mouse cortex of an exogenous gene in a particular population of CNR1-positive cells when a nucleic acid sequence coding for said exogenous gene is operatively linked to said isolated nucleic acid molecule, said particular population of CNR1-positive cells being characterized in that it also expresses EFHD1, ENPP6 and GJC2.[French] La présente invention concerne une molécule d'acide nucléique isolée comprenant ou consistant en la séquence d'acide nucléique de SEQ ID No : 1 ou d'une séquence d'acide nucléique d'au moins 1 400 bp ayant au moins 80 % d'identité avec ladite séquence de SEQ ID No : 1, ladite molécule d'acide nucléique isolée conduisant à l'expression spécifique dans le cortex de souris d'un gène exogène dans une population particulière de cellules CNR1-positives lorsqu'une séquence d'acide nucléique codant pour ledit gène exogène est fonctionnellement liée à ladite molécule d'acide nucléique isolée, ladite population particulière de cellules CNR1-positives étant caractérisée en ce qu'elle exprime également EFHD1, ENPP6 et GJC2.

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