WO2023148527 - SELF-REPLICATING RNA AND USES THEREOF

National phase entry:
Publication Number WO/2023/148527
Publication Date 10.08.2023
International Application No. PCT/IB2022/051021
International Filing Date 07.02.2022
Title **
[English] SELF-REPLICATING RNA AND USES THEREOF
[French] ARN AUTORÉPLIQUANT ET UTILISATIONS ASSOCIÉES
Applicants **
SEQIRUS INC.
Inventors
ALLEN, Pirada
DE SOUZA, Ivna
WEN, Yingxia
CHANG, Cheng
LEE, Changkeun
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2704
EPO Filing, Examination, Granting19940
Japan Filing, Examination, Granting2618
South Korea Filing, Examination, Granting2923
USA Filing, Examination, Granting9110
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Total: 37,295

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Abstract[English] The present disclosure relates to self-replicating RNA encoding an antigen from severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) and uses thereof. Specifically, the disclosure provides a self-replicating RNA or a monocistronic self-replicating RNA comprising a nucleotide sequence encoding an antigen operably linked to a'subgenomic promoter, wherein the antigen is from SARS-CoV-2, and is a spike (S) protein or a nucleocapsid (N) protein.[French] La présente divulgation concerne un ARN autorépliquant codant pour un antigène du coronavirus 2 du syndrome respiratoire aigu sévère (SARS-CoV-2) et des utilisations associées. Spécifiquement, la divulgation concerne un ARN autorépliquant ou un ARN autorépliquant monocistronique comprenant une séquence nucléotidique codant pour un antigène lié de manière fonctionnelle à un promoteur subgénomique, l'antigène provenant du SARS-CoV-2 et étant une protéine spike (S) ou une protéine de nucléocapside (N).

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