WO2022157747 - PHARMACEUTICAL GLP PEPTIDE COMPOSITIONS AND METHODS OF PREPARATION THEREOF

National phase entry:
Publication Number WO/2022/157747
Publication Date 28.07.2022
International Application No. PCT/IB2022/050644
International Filing Date 25.01.2022
Title **
[English] PHARMACEUTICAL GLP PEPTIDE COMPOSITIONS AND METHODS OF PREPARATION THEREOF
[French] COMPOSITIONS PEPTIDIQUES PHARMACEUTIQUES ET LEURS PROCÉDÉS DE PRÉPARATION
Applicants **
MYLAN IRELAND LIMITED
Inventors
BANASIAK, Katarzyna
SIVADAS, Neeraj
FITZGERALD, Michael, Paul
DOWNES, Claire
CARR, Paul
Priority Data
63/141,230   25.01.2021   US
63/189,863   18.05.2021   US
63/226,020   27.07.2021   US
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Quotation for National Phase entry

Country StagesTotal
China Filing, Examination, Granting2569
EPO Filing, Examination, Granting13339
Japan Filing, Examination, Granting2452
South Korea Filing, Examination, Granting2652
USA Filing, Examination, Granting8540
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Total: 29,552

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Abstract[English] Disclosed herein is a stabilized peptide composition that includes a glucagon-like peptide and a stabilizer. The stabilizer may be a stabilizing peptide having the same amino acid sequence as the glucagon-like peptide except the stabilizing peptide has at least one sequence alteration that may be a truncation, a deletion, a substitution and/or an insertion. Also disclosed are methods for making the stabilized peptide composition and its use for treating patients in need thereof.[French] L'invention concerne une composition peptidique stabilisée qui comprend un peptide de type glucagon et un stabilisant. Le stabilisant peut être un peptide de stabilisation présentant la même séquence d'acides aminés que le peptide de type glucagon, à l'exception du peptide de stabilisation, et présente au moins une altération de séquence qui peut être une troncature, une délétion, une substitution et/ou une insertion. L'invention concerne également des procédés de fabrication de la composition peptidique stabilisée et son utilisation pour traiter des patients en ayant besoin.

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