WO2025261952 - PRODUCTION OF UNCONVENTIONAL T CELLS
National phase entry is expected:
Publication Number
WO/2025/261952
Publication Date
26.12.2025
International Application No.
PCT/EP2025/066702
International Filing Date
16.06.2025
Title **
[English]
PRODUCTION OF UNCONVENTIONAL T CELLS
[French]
PRODUCTION DE LYMPHOCYTES T NON CONVENTIONNELS
Applicants **
UNIVERSITEIT GENT
Inventors
JANSEN, Hanne
VANDEKERCKHOVE, Bart
PILLE, Melissa
BILLIET, Lore
Priority Data
24182650.2
17.06.2024
EP
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
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| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1878 | |
| EPO | Filing, Examination, Granting | 8133 | |
| Japan | Filing, Examination, Granting | 1773 | |
| South Korea | Filing, Examination, Granting | 1246 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
17,770
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Abstract[English]
The current invention relates to the field of in vitro culturing of T cells, more in particular of in vitro production of unconventional T cells expressing specific markers. Indeed, the present invention discloses a method to produce said unconventional T cells comprising the generation of hybrid spheroids out of combining stem cells and adherent cells and further culturing said spheroids at the air liquid interface. The latter T cells can be used to produce CAR-T cells.[French]
La présente invention concerne le domaine de la culture in vitro de lymphocytes T, plus particulièrement de la production in vitro de lymphocytes T non conventionnels exprimant des marqueurs spécifiques. En effet, la présente invention concerne un procédé de production desdits lymphocytes T non conventionnels comprenant la génération de sphéroïdes hybrides hors de la combinaison de cellules souches et de cellules adhérentes et la culture supplémentaire desdits sphéroïdes au niveau de l'interface air-liquide. Ces derniers lymphocytes T peuvent être utilisés pour produire des lymphocytes T-CAR.