WO2025201979 - A METHOD FOR DEFATTENING A STEATOTIC LIVER EX VIVO BY PERFUSION USING A PI4KB INHIBITOR
National phase entry is expected:
Publication Number
WO/2025/201979
Publication Date
02.10.2025
International Application No.
PCT/EP2025/057453
International Filing Date
19.03.2025
Title **
[English]
A METHOD FOR DEFATTENING A STEATOTIC LIVER EX VIVO BY PERFUSION USING A PI4KB INHIBITOR
[French]
PROCÉDÉ D'ÉLIMINATION EX VIVO DE LA GRAISSE D'UN FOIE ATTEINT DE STÉATOSE HÉPATIQUE PAR PERFUSION À L'AIDE D'UN INHIBITEUR DE PI4KB
Applicants **
ETH ZURICH
Inventors
WOLFRUM, Christian
TIBBITT, Mark
DING, Lianggong
HOFFMANN, Waldemar
HUWYLER, Florian
BINZ, Jonas
Priority Data
24166005.9
25.03.2024
EP
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2389 | |
| EPO | Filing, Examination, Granting | 9592 | |
| Japan | Filing, Examination, Granting | 2169 | |
| South Korea | Filing, Examination, Granting | 2050 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
20,940
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Abstract[English]
The present invention relates to a method for defattening a steatotic liver ex vivo, the method comprising perfusing a steatotic liver graft in a perfusion step using a perfusate comprising a PI4KB inhibitor as specified or a pharmaceutically acceptable salt or solvate thereof.[French]
La présente invention concerne un procédé d'élimination ex vivo de la graisse d'un foie atteint de stéatose hépatique, le procédé comprenant la perfusion d'un greffon de foie stéatosique dans une étape de perfusion à l'aide d'un perfusat contenant un inhibiteur de PI4KB tel que spécifié ou un sel ou solvate pharmaceutiquement acceptable de celui-ci.