WO2025157996 - MEANS AND METHODS FOR THE INDUCTION OF PROTEIN DEGRADATION
National phase entry is expected:
Publication Number
WO/2025/157996
Publication Date
31.07.2025
International Application No.
PCT/EP2025/051802
International Filing Date
24.01.2025
Title **
[English]
MEANS AND METHODS FOR THE INDUCTION OF PROTEIN DEGRADATION
[French]
MOYENS ET PROCÉDÉS D'INDUCTION DE DÉGRADATION DE PROTÉINES
Applicants **
VIB VZW
KATHOLIEKE UNIVERSITEIT LEUVEN
Inventors
ROUSSEAU, Frederic
SCHYMKOWITZ, Joost
HOUBEN, Bert
DURAN-ROMAÑA, Ramon
Priority Data
24154112.7
26.01.2024
EP
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
* |
| Type of Assignment |
The Standard Agent's Assignment
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Patent Delivery |
Send the Letters Patent by Courier
* |
| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1993 | |
| EPO | Filing, Examination, Granting | 8561 | |
| Japan | Filing, Examination, Granting | 1890 | |
| South Korea | Filing, Examination, Granting | 1500 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
18,684
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Abstract[English]
The invention provides means and methods to identify amino acids in target proteins which are crucial weak spots for the native protein stability. Such regions are useful for screening of compounds interacting with such amino acid regions. Compounds identified with this technology can induce the misfolding and subsequent cellular degradation of a target protein.[French]
L'invention concerne des moyens et des procédés destinés à identifier des acides aminés dans des protéines cibles qui sont des points faibles cruciaux pour la stabilité de protéine native. De telles régions sont utiles pour le criblage de composés interagissant avec de telles régions d'acides aminés. Les composés identifiés avec cette technologie peuvent induire le mauvais repliement et la dégradation cellulaire ultérieure d'une protéine cible.