WO2023170028 - METHOD FOR REDUCING ENDOTOXIN LEVELS IN NUCLEIC ACID PURIFICATION
National phase entry:
Publication Number
WO/2023/170028
Publication Date
14.09.2023
International Application No.
PCT/EP2023/055677
International Filing Date
07.03.2023
Title **
[English]
METHOD FOR REDUCING ENDOTOXIN LEVELS IN NUCLEIC ACID PURIFICATION
[French]
PROCÉDÉ DE RÉDUCTION DES TAUX D'ENDOTOXINES LORS DE LA PURIFICATION D'ACIDES NUCLÉIQUES
Applicants **
MERCK PATENT GMBH
Inventors
HEINEN-KREUZIG, Anja
KIESEWETTER, Andre
LUTZ, Herbert
GUPTA, Akshat
Priority Data
63/318,548
10.03.2022
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
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| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
* |
| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2005 | |
| EPO | Filing, Examination, Granting | 8131 | |
| Japan | Filing, Examination, Granting | 2130 | |
| South Korea | Filing, Examination, Granting | 1994 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
19,000
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
The present invention relates to a method for reducing endotoxin levels or removing endotoxins from nucleic acids. For this a zwitterionic detergent selected from the group of amine oxides or mixtures thereof is added during anion exchange chromatographic purification of the nucleic acids using a membrane or monolith-based sorbent.[French]
La présente invention concerne un procédé de réduction des taux d'endotoxine ou d'élimination d'endotoxines d'acides nucléiques. Un détergent zwitterionique choisi dans le groupe des oxydes d'amine ou des mélanges de ceux-ci est ajouté pendant la purification chromatographique par échange d'anions des acides nucléiques à l'aide d'une membrane ou d'un sorbant à base de monolithe.