WO2023030667 - PROCESS FOR THE PREPARATION OF CHLOROALKYL SUBSTITUTED CYCLIC AMINES
National phase entry:
Publication Number
WO/2023/030667
Publication Date
09.03.2023
International Application No.
PCT/EP2021/075830
International Filing Date
20.09.2021
Title **
[English]
PROCESS FOR THE PREPARATION OF CHLOROALKYL SUBSTITUTED CYCLIC AMINES
[French]
PROCÉDÉ DE PRÉPARATION D'AMINES CYCLIQUES À SUBSTITUTION CHLOROALKYLE
Applicants **
HOVIONE FARMACIENCIA SA
TURNER, Craig
Inventors
KATZ, Marianna
TORRES, Nuno
SOBRAL, Luis
ANTUNES, Rafael
Priority Data
117440
03.09.2021
PT
Application details
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter II
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| Patent Delivery |
Send the Letters Patent by Courier
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2345 | |
| EPO | Filing, Examination, Granting | 11536 | |
| Japan | Filing, Examination, Granting | 2393 | |
| South Korea | Filing, Examination, Granting | 2435 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
23,449
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
A process for the preparation of a compound of formula (II) where Et = ethyl; Bn = benzyl and Ph = phenyl; comprises the step of reacting a cyclic amine with an alkylating agent to form a compound of formula II, wherein the process is solvent-free.The chloroalkyl N-substituted cyclic amines of formula II may be used in the preparation of active pharmaceutical ingredients or intermediates therefor comprising these moieties in their molecular structure.[French]
Un procédé de préparation d'un composé de formule (II) où Et = éthyle ; Bn = benzyle et Ph = phényle ; comprend l'étape consistant à faire réagir une amine cyclique avec un agent alkylant pour former un composé de formule II, le procédé étant exempt de solvant. Les amines cycliques N-substituées de chloroalkyle de formule II peuvent être utilisées dans la préparation d'ingrédients pharmaceutiques actifs ou d'intermédiaires associés comprenant ces fractions dans leur structure moléculaire.