WO2023016621 - TERNARY COMPLEX DETERMINATION FOR PLAUSIBLE TARGETED PROTEIN DEGRADATION USING DEEP LEARNING AND DESIGN OF DEGRADER MOLECULES USING DEEP LEARNING
National phase entry is expected:
Publication Number
WO/2023/016621
Publication Date
16.02.2023
International Application No.
PCT/EP2021/025372
International Filing Date
29.09.2021
Title **
[English]
TERNARY COMPLEX DETERMINATION FOR PLAUSIBLE TARGETED PROTEIN DEGRADATION USING DEEP LEARNING AND DESIGN OF DEGRADER MOLECULES USING DEEP LEARNING
[French]
DÉTERMINATION DE COMPLEXE TERNAIRE CONCERNANT LA DÉGRADATION DE PROTÉINES CIBLÉES PLAUSIBLES À L'AIDE D'UN APPRENTISSAGE PROFOND ET DE LA CONCEPTION DE MOLÉCULES DE DÉGRADATION À L'AIDE D'UN APPRENTISSAGE PROFOND
Applicants **
CELERIS THERAPEUTICS GMBH
Inventors
TRUMMER, Christopher
RAO, Arjun
ORASCH, Oliver
FLECK, Markus
FOOLADI, Hosein
WEBER, Noah
Priority Data
A138/2021
12.08.2021
AT
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
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| Pages of Specification | * |
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| Number of Office Actions | * |
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International Searching Authority |
EPO
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1879 | |
| EPO | Filing, Examination, Granting | 8149 | |
| Japan | Filing, Examination, Granting | 1983 | |
| South Korea | Filing, Examination, Granting | 1680 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
18,431
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
The invention is related to a computer implemented, machine learning based method for determining ternary complexes in targeted protein degradation, by representing biomolecules as graphs and then feeding these graphs as inputs into a machine learning system comprising steps of - determination of the 3D structure of relevant proteins (1) determination of the interactions between each fragment of the degrader and the cor-responding proteins as well as identification of the corresponding interaction (2) Protein-Protein complex prediction (3) Refinement of the ternary complex, with the designed linker (4).[French]
L'invention concerne un procédé mis en œuvre par ordinateur et basé sur l'apprentissage automatique permettant de déterminer des complexes ternaires dans la dégradation de protéines ciblées, par représentation de biomolécules en tant que graphiques, puis par fourniture de ces graphiques en tant qu'entrées dans un système d'apprentissage automatique comprenant des étapes de détermination de la structure 3D de protéines pertinentes (1) détermination des interactions entre chaque fragment de l'agent de dégradation et les protéines correspondantes ainsi que l'identification de l'interaction correspondante (2) prédiction de complexe protéine-protéine (3) affinement du complexe ternaire, à l'aide du lieur conçu (4).