WO2026108752 - METHOD FOR INCREASING OR IMPROVING NITRIC OXIDE SIGNALS OR LEVELS, AND COMPOSITION
National phase entry is expected:
Publication Number
WO/2026/108752
Publication Date
28.05.2026
International Application No.
PCT/CN2025/135285
International Filing Date
17.11.2025
Title **
[English]
METHOD FOR INCREASING OR IMPROVING NITRIC OXIDE SIGNALS OR LEVELS, AND COMPOSITION
[French]
PROCÉDÉ POUR AUGMENTER OU AMÉLIORER DES SIGNAUX OU DES NIVEAUX D'OXYDE NITRIQUE, ET COMPOSITION
[Chinese]
用于增加或改善一氧化氮信号或水平的方法和组合物
Applicants **
NANJING NUTRABUILDING BIO-TECH CO., LTD.
Inventors
ZHANG, Qianjing
WELLS, Shawn
LIAO, Kylin
Priority Data
PCT/CN2024/132831
19.11.2024
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2587 | |
| EPO | Filing, Examination, Granting | 26984 | |
| Japan | Filing, Examination, Granting | 3101 | |
| South Korea | Filing, Examination, Granting | 4072 | |
| USA | Filing, Examination, Granting | 10940 |
Total:
47,684
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Abstract[English]
A method for increasing or improving nitric oxide signals or levels, the method comprising: administering a composition to a subject, the composition comprising: arginine or a pharmaceutically acceptable salt, ester, or derivative thereof; and tetrahydrocurcumin and/or β-aminoisobutyric acid or a pharmaceutically acceptable salt or ester thereof. The method and the composition can be used to increase, improve, or enhance nitric oxide signals or levels, inhibit nitric oxide decomposition, and increase or enhance nitrous acid and/or cyclic guanosine monophosphate levels, and can improve fatigue resistance or enhance muscle strength, maintain or improve cardiovascular health, maintain or improve vascular function and structure, inhibit or mitigate endothelial cell damage, or mitigate insufficient blood flow.[French]
L'invention concerne un procédé d'augmentation ou d'amélioration de signaux ou de niveaux d'oxyde nitrique, le procédé consistant à : administrer une composition à un sujet, la composition contenant : de l'arginine ou un sel, un ester ou un dérivé pharmaceutiquement acceptable de celle-ci ; et de la tétrahydrocurcumine et/ou de l'acide β-aminoisobutyrique ou un sel ou ester pharmaceutiquement acceptable de celui-ci. Le procédé et la composition peuvent être utilisés pour augmenter, améliorer ou renforcer des signaux ou des niveaux d'oxyde nitrique, inhiber la décomposition de l'oxyde nitrique, et augmenter ou améliorer les niveaux d'acide nitreux et/ou de monophosphate de guanosine cyclique, et peuvent améliorer la résistance à la fatigue ou améliorer la force musculaire, maintenir ou améliorer la santé cardiovasculaire, maintenir ou améliorer la fonction et la structure vasculaires, inhiber ou atténuer les lésions des cellules endothéliales, ou atténuer l’insuffisance du débit sanguin.[Chinese]
一种增加或改善一氧化氮信号或水平的方法，包括：向受试者施用组合物，组合物包含精氨酸或其药学上可接受的盐、酯、衍生物；和四氢姜黄素和/或β-氨基异丁酸或其药学上可接受的盐、酯。该方法和组合物可以用于增加或改善或提高一氧化氮信号或水平，抑制一氧化氮分解，以及增加或提高亚硝酸和/或环磷酸鸟苷的水平，可以提高抗疲劳能力或增强肌肉力量，维持或改善心血管健康，维持或改善血管功能和结构，抑制或减轻内皮细胞损伤，或减轻血流不足。