WO2026103742 - DEUTERATED FUSED RING COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2026/103742
Publication Date
21.05.2026
International Application No.
PCT/CN2025/134414
International Filing Date
12.11.2025
Title **
[English]
DEUTERATED FUSED RING COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
[French]
COMPOSÉ CYCLIQUE FUSIONNÉ DEUTÉRÉ, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
[Chinese]
一种氘代稠环化合物及其制备方法与用途
Applicants **
JIANGSU NHWA PHARMACEUTICAL CO., LTD
Inventors
GUO, Qiang
ZHAO, Song
WANG, Wei
XU, Xiangqing
LI, Quxiang
TIAN, Liwei
YU, Minquan
DONG, Yingying
WANG, Weinan
SUN, Kai
LI, Xuewei
ZHANG, Chang
LI, Dongdong
Priority Data
202411624054.5
14.11.2024
CN
202510566922.7
30.04.2025
CN
202510782119.7
12.06.2025
CN
202510938927.8
08.07.2025
CN
202511118818.8
11.08.2025
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2303 | |
| EPO | Filing, Examination, Granting | 15181 | |
| Japan | Filing, Examination, Granting | 2337 | |
| South Korea | Filing, Examination, Granting | 2562 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
27,123
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Abstract[English]
Provided in the present invention is a deuterated fused ring compound. In particular, the present invention relates to a compound represented by general formula (II), a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of the stereoisomer thereof. The present invention also relates to a pharmaceutical composition containing the compound, a preparation method therefor, and a method and use thereof for treating pain, especially pain related to opioid receptor activation. Substituents in general formula (II) are as defined in the description.[French]
La présente invention concerne un composé cyclique fusionné deutéré. En particulier, la présente invention concerne un composé représenté par la formule générale (II), un stéréoisomère de celui-ci, un sel pharmaceutiquement acceptable de celui-ci, ou un sel pharmaceutiquement acceptable du stéréoisomère de celui-ci. La présente invention concerne également une composition pharmaceutique contenant le composé, son procédé de préparation, et son procédé et son utilisation pour le traitement de la douleur, en particulier de la douleur liée à l'activation du récepteur opioïde. Les substituants dans la formule générale (II) sont tels que définis dans la description.[Chinese]
本发明涉及一种氘代稠环化合物。特别地，本发明涉及通式(II)所示的化合物、其立体异构体、其药学上可接受的盐、或其立体异构体的药学上可接受的盐。本发明还涉及含有该化合物的药物组合物，其制备方法，以及其用于治疗疼痛、尤其是与阿片受体激活相关疼痛的方法和用途。其中，通式(II)中的各取代基与说明书中的定义相同。