WO2026098499 - DOUBLE-STRANDED SIRNA ANALOG FOR INHIBITING MSTN EXPRESSION, PREPARATION METHOD THEREFOR, AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2026/098499
Publication Date
15.05.2026
International Application No.
PCT/CN2025/132711
International Filing Date
05.11.2025
Title **
[English]
DOUBLE-STRANDED SIRNA ANALOG FOR INHIBITING MSTN EXPRESSION, PREPARATION METHOD THEREFOR, AND USE THEREOF
[French]
ANALOGUE D'ARNSI DOUBLE BRIN POUR INHIBER L'EXPRESSION DE MSTN, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
[Chinese]
用于抑制MSTN表达的双链siRNA类似物及其制备方法和用途
Applicants **
SHENZHEN SALUBRIS PHARMACEUTICALS CO., LTD
Inventors
JIANG, Wenjuan
LI, Jiani
Priority Data
202411573726.4
05.11.2024
CN
202411758019.2
03.12.2024
CN
202510280171.2
10.03.2025
CN
202510709041.6
29.05.2025
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1797 | |
| EPO | Filing, Examination, Granting | 11629 | |
| Japan | Filing, Examination, Granting | 2078 | |
| South Korea | Filing, Examination, Granting | 2022 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
22,266
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Abstract[English]
Provided are a double-stranded siRNA analog for inhibiting myostatin (MSTN) expression, a preparation method therefor, and use thereof. The double-stranded siRNA analog can inhibit MSTN expression and be used for preventing and/or treating MSTN-related diseases and disorders, such as myoatrophy.[French]
L'invention concerne un analogue d'ARNsi double brin pour inhiber l'expression de la myostatine (MSTN), son procédé de préparation et son utilisation. L'analogue d'ARNsi double brin peut inhiber l'expression de MSTN et être utilisé pour prévenir et/ou traiter des maladies et troubles liés à MSTN, tels que l'atrophie musculaire.[Chinese]
提供用于肌肉生长抑制素(MSTN)表达的双链siRNA类似物及其制备方法和用途，所述双链siRNA类似物可以抑制MSTN的表达，用于预防和/或治疗MSTN相关疾病和病症，例如肌萎缩。