WO2026091937 - PREPARATION AND USE OF NEW ANTICANCER DRUG TNBG-D COMPOUND
National phase entry is expected:
Publication Number
WO/2026/091937
Publication Date
07.05.2026
International Application No.
PCT/CN2025/121624
International Filing Date
16.09.2025
Title **
[English]
PREPARATION AND USE OF NEW ANTICANCER DRUG TNBG-D COMPOUND
[French]
PRÉPARATION ET UTILISATION D'UN NOUVEAU COMPOSÉ MÉDICAMENT ANTICANCÉREUX TNBG-D
[Chinese]
一种新型的抗癌药物TNBG-D化合物的制备与应用
Applicants **
CHONGQING MEDICAL UNIVERSITY
Inventors
YU, Yu
YI, Chengwan
FU, Xianwu
ZHU, Dali
XIE, Yun
Priority Data
202411555788.2
04.11.2024
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1574 | |
| EPO | Filing, Examination, Granting | 11600 | |
| Japan | Filing, Examination, Granting | 1961 | |
| South Korea | Filing, Examination, Granting | 1654 | |
| USA | Filing, Examination, Granting | 7140 |
Total:
23,929
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Abstract[English]
The present invention belongs to the field of chemical medicine. Provided in the present invention are the preparation and use of a new anticancer drug TNBG-D compound. In the present invention, the structure of the anticancer drug TNBG is simplified, i.e., by deleting a D ring (benzene ring), to obtain a series of compounds represented by formula I or salts or stereoisomers thereof. The anticancer drug TNBG-D compound of the present invention and a formulation prepared therefrom with a suitable excipient or auxiliary ingredient have good inhibitory effects on solid tumor cells such as liver cancer, lung cancer and breast cancer, and non-solid tumor cells such as hematologic tumors, possess the potential for treating both solid and non-solid tumors, and have broad prospects for research and application.[French]
La présente invention relève du domaine de la médecine chimique. La présente invention concerne la préparation et l'utilisation d'un nouveau composé médicament anticancéreux TNBG-D. Dans la présente invention, la structure du médicament anticancéreux TNBG est simplifiée, c'est-à-dire par délétion d'un cycle D (cycle benzène), pour obtenir une série de composés représentés par la formule I ou leurs sels ou stéréoisomères. Le composé médicament anticancéreux TNBG-D selon la présente invention et une formulation préparée à partir de celui-ci avec un excipient ou un ingrédient auxiliaire approprié ont de bons effets inhibiteurs sur des cellules tumorales solides telles que le cancer du foie, le cancer du poumon et le cancer du sein, et des cellules tumorales non solides telles que des tumeurs hématologiques, possèdent le potentiel de traitement à la fois de tumeurs solides et non solides, et ont de larges perspectives pour la recherche et l'application.[Chinese]
本发明提供了一种新型的抗癌药物TNBG-D化合物的制备与应用，属于化学医药领域。本发明对抗癌药物TNBG结构进行简化，即删除D环(苯环)，得到一系列式I所示的化合物或其盐或其立体异构体。本发明的抗癌药物TNBG-D化合物及其配以合适的辅料或辅助性成分制备而成的制剂对例如肝癌、肺癌、乳腺癌等实体瘤细胞以及血液瘤等非实体瘤细胞具有较好的抑制作用，具备用于治疗实体瘤与非实体瘤的潜力，有广阔的研究与应用前景。