WO2026040943 - METHOD FOR PREPARING α-CHIRAL CARBOXYLIC ACID OR α-CHIRAL ESTER BY MEANS OF ENZYME CATALYSIS
National phase entry is expected:
Publication Number
WO/2026/040943
Publication Date
26.02.2026
International Application No.
PCT/CN2025/115258
International Filing Date
18.08.2025
Title **
[English]
METHOD FOR PREPARING α-CHIRAL CARBOXYLIC ACID OR α-CHIRAL ESTER BY MEANS OF ENZYME CATALYSIS
[French]
PROCÉDÉ DE PRÉPARATION D'ACIDE CARBOXYLIQUE ALPHA-CHIRAL OU D'ESTER ALPHA-CHIRAL PAR CATALYSE ENZYMATIQUE
[Chinese]
一种酶催化制备α-手性羧酸或α-手性酯的方法
Applicants **
ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.
Inventors
JI, Rong
WANG, Luping
YANG, Rendi
LIU, Jian
ZHANG, Junjie
WANG, Xiaofei
DONG, Haiwei
HUANG, Wenfeng
GONG, Yulong
TIAN, Peng
SONG, Yueyi
XU, Haoran
ZHU, Xiaoren
ZHU, Wei
MENG, Yanhua
Priority Data
202411144703.1
19.08.2024
CN
202411333741.1
24.09.2024
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1747 | |
| EPO | Filing, Examination, Granting | 11688 | |
| Japan | Filing, Examination, Granting | 2108 | |
| South Korea | Filing, Examination, Granting | 2025 | |
| USA | Filing, Examination, Granting | 5940 |
Total:
23,508
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Abstract[English]
The present invention relates to the field of pharmaceutical chemistry, and relates to a method for preparing an α-chiral carboxylic acid and/or an α-chiral ester by means of enzyme catalysis. Specifically, the present invention provides a method for preparing a compound of formula II (α-chiral carboxylic acid) and/or a compound of formula III (α-chiral ester). The method has technical advantages such as high efficiency and high chiral purity of a product.[French]
La présente invention concerne le domaine de la chimie pharmaceutique, et concerne un procédé de préparation d'un acide carboxylique alpha-chiral et/ou d'un ester alpha-chiral par catalyse enzymatique. Plus particulièrement, la présente invention concerne un procédé de préparation d'un composé de formule II (acide carboxylique alpha-chiral) et/ou d'un composé de formule III (ester alpha-chiral). Le procédé présente des avantages techniques tels qu'une efficacité élevée et une pureté chirale élevée d'un produit.[Chinese]
本发明涉及一种酶催化制备α-手性羧酸和/或α-手性酯的方法，属于医药化工领域。具体而言，本发明提供了一种制备式Ⅱ化合物(α-手性羧酸)和/或式Ⅲ化合物(α-手性酯)的方法，该方法具有效率高，产物手性纯度高等技术优势。