WO2026026886 - ULTRA-SHORT-ACTING NEUROMUSCULAR BLOCKING AGENT, PREPARATION METHOD THEREFOR, AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2026/026886
Publication Date
05.02.2026
International Application No.
PCT/CN2025/111645
International Filing Date
31.07.2025
Title **
[English]
ULTRA-SHORT-ACTING NEUROMUSCULAR BLOCKING AGENT, PREPARATION METHOD THEREFOR, AND USE THEREOF
[French]
AGENT DE BLOCAGE NEUROMUSCULAIRE À ACTION ULTRA-COURTE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
[Chinese]
一种超短效神经肌肉阻滞剂及其制备方法和用途
Applicants **
JIANGSU NHWA PHARMACEUTICAL CO., LTD
Inventors
MO, Qingmei
DOU, Fei
ZHANG, Yi
WANG, Dongli
YANG, Qinglu
JI, Haili
WANG, Wei
ZHANG, Datong
LI, Ruibo
WANG, Wei
XU, Xiangqing
Priority Data
202411054280.4
02.08.2024
CN
202411591598.6
08.11.2024
CN
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2978 | |
| EPO | Filing, Examination, Granting | 23928 | |
| Japan | Filing, Examination, Granting | 2761 | |
| South Korea | Filing, Examination, Granting | 3389 | |
| USA | Filing, Examination, Granting | 7990 |
Total:
41,046
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Abstract[English]
The present invention relates to a biquaternary ammonium salt compound having an ultra-short-acting neuromuscular blocking function. In particular, the present invention relates to a compound represented by general formula (I-2), or a stereoisomer thereof, a pharmaceutically acceptable salt or co-crystal thereof, a pharmaceutically acceptable salt or co-crystal of the stereoisomer thereof, a solvate thereof, a prodrug thereof, a deuterated derivative thereof, or a metabolite thereof. The present invention also relates to a pharmaceutical composition containing the compound, a preparation method therefor, and the function and use thereof in neuromuscular blockade. Each substituent in the general formula (I-2) is as defined in the description.[French]
La présente invention concerne un composé sel d'ammonium biquaternaire ayant une fonction de blocage neuromusculaire à action ultra-courte. En particulier, la présente invention concerne un composé représenté par la formule générale (I-2), ou un stéréoisomère de celui-ci, un sel ou un co-cristal pharmaceutiquement acceptable de celui-ci, un sel ou co-cristal pharmaceutiquement acceptable du stéréoisomère de celui-ci, un solvate de celui-ci, un promédicament de celui-ci, un dérivé deutéré de celui-ci, ou un métabolite de celui-ci. La présente invention concerne également une composition pharmaceutique contenant le composé, son procédé de préparation, et sa fonction et son utilisation dans le blocage neuromusculaire. Chaque substituant dans la formule générale (I-2) est tel que défini dans la description.[Chinese]
本发明涉及一种具有超短效神经肌肉阻滞功能的双季铵盐化合物。特别地，本发明涉及通式(I-2)所示的化合物、或其立体异构体、其药学上可接受的盐或共晶，其立体异构体的药学上可接受的盐或共晶、其溶剂化物、其前药、其氘代衍生物、或其代谢产物。本发明还涉及含有该化合物的药物组合物，制备方法，及其在神经肌肉阻滞中的功能及用途。其中，通式(I-2)中的各取代基与说明书中的定义相同。