WO2025247357 - CLASS OF CD73 INHIBITORS WITH OXOAROMATIC HETEROCYCLIC STRUCTURE, PREPARATION METHODS THEREFOR, PHARMACEUTICAL COMPOSITIONS THEREOF, AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2025/247357
Publication Date
04.12.2025
International Application No.
PCT/CN2025/098222
International Filing Date
30.05.2025
Title **
[English]
CLASS OF CD73 INHIBITORS WITH OXOAROMATIC HETEROCYCLIC STRUCTURE, PREPARATION METHODS THEREFOR, PHARMACEUTICAL COMPOSITIONS THEREOF, AND USE THEREOF
[French]
CLASSE D'INHIBITEURS DE CD73 À STRUCTURE HÉTÉROCYCLIQUE OXOAROMATIQUE, PROCÉDÉS DE PRÉPARATION S'Y RAPPORTANT, COMPOSITIONS PHARMACEUTIQUES ASSOCIÉES ET UTILISATION ASSOCIÉE
[Chinese]
一类氧代芳杂环结构的CD73抑制剂、及其制法和药物组合物与用途
Applicants **
INSTITUTE OF MATERIA MEDICA ,CHINESE ACADEMY OF MEDICAL SCICENCES
Inventors
FENG, Zhiqiang
TANG, Zhenbo
Priority Data
202410694911.2
31.05.2024
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2168 | |
| EPO | Filing, Examination, Granting | 13768 | |
| Japan | Filing, Examination, Granting | 2049 | |
| South Korea | Filing, Examination, Granting | 1854 | |
| USA | Filing, Examination, Granting | 5190 |
Total:
25,029
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Abstract[English]
The present invention pertains to the technical field of medicines. Disclosed are a class of oxoaromatic heterocyclic derivatives, preparation methods therefor, pharmaceutical compositions thereof, and use thereof. Specifically, the present invention relates to a class of oxoaromatic heterocyclic derivatives represented by general formula I, pharmaceutically acceptable salts thereof, stereoisomers thereof, preparation methods therefor, compositions comprising one or more of the compounds, and use of the compounds in the treatment of CD73-related diseases, such as tumors, cancer, inflammation-related diseases, immune diseases, diseases of the nervous system, neurodegenerative diseases, diseases of the central nervous system, depression, Parkinson’s disease, sleep disorders, fibrosis, and cerebral and cardiac ischemic diseases.[French]
La présente invention se rapporte au domaine technique des médicaments. Sont divulgués une classe de dérivés hétérocycliques oxoaromatiques, des procédés de préparation s'y rapportant, des compositions pharmaceutiques associées, et une utilisation associée. Plus particulièrement, la présente invention se rapporte à une classe de dérivés hétérocycliques oxoaromatiques représentés par la formule générale I, des sels pharmaceutiquement acceptables de ceux-ci, des stéréoisomères de ceux-ci, des procédés de préparation s'y rapportant, des compositions comprenant un ou plusieurs des composés, et l'utilisation des composés dans le traitement de maladies associées à CD73, telles que tumeurs, cancer, maladies associées à l'inflammation, maladies immunitaires, maladies du système nerveux, maladies neurodégénératives, maladies du système nerveux central, dépression, maladie de Parkinson, troubles du sommeil, fibrose et maladies ischémiques cérébrales et cardiaques.[Chinese]
本发明属于医药技术领域，公开了一类氧代芳杂环衍生物、及其制法和药物组合物与用途。具体而言，涉及通式I所示的一类氧代芳杂环衍生物，其可药用盐，其立体异构体及其制备方法，含有一个或多个这化合物的组合物，和该类化合物在治疗与CD73有关的疾病如肿瘤、癌症、炎症相关疾病、免疫相关疾病、神经系统疾病、神经变性疾病、中枢神经系统疾病、抑郁症、帕金森氏疾病、睡眠障碍和纤维化、脑和心脏缺血性疾病方面的用途。