WO2025228279 - WHEAT EPSPS MUTANT PROTEIN AND USE THEREOF IN HERBICIDE RESISTANCE
National phase entry is expected:
Publication Number
WO/2025/228279
Publication Date
06.11.2025
International Application No.
PCT/CN2025/091381
International Filing Date
27.04.2025
Title **
[English]
WHEAT EPSPS MUTANT PROTEIN AND USE THEREOF IN HERBICIDE RESISTANCE
[French]
PROTÉINE MUTANTE EPSPS DE BLÉ ET UTILISATION ASSOCIÉE DANS LA RÉSISTANCE AUX HERBICIDES
[Chinese]
小麦EPSPS突变蛋白及其在抗除草剂上的应用
Applicants **
QINGDAO KINGAGROOT SEED SCIENCE CO., LTD.
Inventors
WANG, Lei
MO, Sudong
YUAN, Kun
WANG, Jiyao
Priority Data
202410518039.6
28.04.2024
CN
202510240189.X
01.03.2025
CN
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CNIPA
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The Standard Agent's Assignment
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Chapter I
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1747 | |
| EPO | Filing, Examination, Granting | 11653 | |
| Japan | Filing, Examination, Granting | 2144 | |
| South Korea | Filing, Examination, Granting | 2083 | |
| USA | Filing, Examination, Granting | 4740 |
Total:
22,367
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Abstract[English]
The present invention relates to the fields of agriculture, plant biotechnology, and molecular biology. Specifically, the present invention relates to a wheat EPSPS mutant protein and use thereof in improving the tolerance of wheat to glyphosate. The mutant protein comprises an amino acid sequence having the following mutations compared to the EPSPS amino acid sequence of any genome of wild-type wheat: in the amino acid sequence set forth in SEQ ID NO: 2, the amino acid at position 168 is mutated from threonine to isoleucine, the amino acid at position 169 is mutated from alanine to valine, and the amino acid at position 172 is mutated from proline to serine. The mutant protein enables the production of stable glyphosate-resistant wheat, showing important significance for wheat breeding.[French]
La présente invention concerne les domaines de l'agriculture, de la biotechnologie végétale et de la biologie moléculaire. Plus particulièrement, la présente invention concerne une protéine mutante EPSPS de blé et une utilisation associée dans l'amélioration de la tolérance du blé au glyphosate. La protéine mutante comprend une séquence d'acides aminés ayant les mutations suivantes par rapport à la séquence d'acides aminés EPSPS de n'importe quel génome de blé de type sauvage : dans la séquence d'acides aminés présentée dans SEQ ID No 2, l'acide aminé en position 168 est muté de la thréonine en isoleucine, l'acide aminé en position 169 est muté de l'alanine en valine et l'acide aminé en position 172 est muté de la proline en sérine. La protéine mutante permet la production de blé stable résistant au glyphosate, présentant une importance considérable pour la culture du blé.[Chinese]
涉及农业、植物生物技术以及分子生物学领域。具体而言，涉及一种小麦EPSPS突变蛋白及其在提高小麦对草甘膦耐受性上的应用。所述突变蛋白包含与野生型小麦任一基因组的EPSPS氨基酸序列相比具有下述突变的氨基酸序列：在对应于SEQ ID NO:2所示的氨基酸序列中的第168位氨基酸由苏氨酸突变为异亮氨酸；和第169位氨基酸由丙氨酸突变为缬氨酸；和第172位氨基酸由脯氨酸突变为丝氨酸。其能产生稳定的抗草甘膦小麦，对于小麦育种具有重要的意义。