WO2025200610 - CATIONIC LIPID CONTAINING DISULFIDE BOND AND IONIZABLE SIDE GROUP, AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2025/200610
Publication Date
02.10.2025
International Application No.
PCT/CN2024/139425
International Filing Date
13.12.2024
Title **
[English]
CATIONIC LIPID CONTAINING DISULFIDE BOND AND IONIZABLE SIDE GROUP, AND USE THEREOF
[French]
LIPIDE CATIONIQUE CONTENANT UNE LIAISON DISULFURE ET UN GROUPE LATÉRAL IONISABLE ET SON UTILISATION
[Chinese]
一种含二硫键和可离子化侧基的阳离子脂质及其应用
Applicants **
XIAMEN SINOPEG BIOTECH CO., LTD
Inventors
WEI, Guohua
LIN, Sheng
CHEN, Dandan
WANG, Ailan
LIN, Minggui
WENG, Wengui
LIU, Chao
ZHU, Qi
Priority Data
202410365745.1
28.03.2024
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| * | |
| * | |
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2492 | |
| EPO | Filing, Examination, Granting | 18555 | |
| Japan | Filing, Examination, Granting | 2482 | |
| South Korea | Filing, Examination, Granting | 2756 | |
| USA | Filing, Examination, Granting | 5740 |
Total:
32,025
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Abstract[English]
are each independently an azaalkyl group containing 0-1 cyclic structures. The cationic lipid structure of the present invention is constructed by means of a bifunctional disulfide and a small molecule free of disulfide bonds, and the raw materials are readily available. A lipid pharmaceutical composition prepared by means of using the cationic lipid of the present invention achieves an excellent effect in biological activity tests, especially in terms of the transfection efficiency of nucleic acid drugs.[French]
sont chacun indépendamment un groupe azaalkyle contenant 0-1 structure cyclique. La structure lipidique cationique selon la présente invention est construite au moyen d'un disulfure bifonctionnel et d'une petite molécule exempte de liaisons disulfure, et les matières premières sont facilement disponibles. Une composition pharmaceutique lipidique préparée au moyen de l'utilisation du lipide cationique selon la présente invention permet d'obtenir un excellent effet dans des tests d'activité biologique, en particulier en termes d'efficacité de transfection de médicaments d'acide nucléique.[Chinese]
各自独立地为含0-1个环状结构的氮杂烷基。本发明的阳离子脂质结构通过双官能化的二硫化物与不含二硫键的小分子进行构建，原料易得。采用本发明的阳离子脂质制备的脂质药物组合物在生物活性测试中获得了优异的效果，尤其在核酸药物转染效果方面。