WO2025077806 - COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT)
National phase entry:
Publication Number
WO/2025/077806
Publication Date
17.04.2025
International Application No.
PCT/CN2024/124070
International Filing Date
11.10.2024
Title **
[English]
COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT)
[French]
COMPOSITIONS ET PROCÉDÉS POUR INHIBER L'EXPRESSION DE LA PROTÉINE TAU ASSOCIÉE AUX MICROTUBULES (MAPT)
Applicants **
SHANGHAI ARGO BIOPHARMACEUTICAL CO., LTD.
Inventors
SHU, Dongxu
SHAO, Pengcheng Patrick
XIA, Shiwei
Priority Data
PCT/CN2023/123908
11.10.2023
CN
PCT/CN2024/120626
24.09.2024
CN
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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* The data is based on automatic recognition. Please verify and amend if necessary.
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 4676 | |
| EPO | Filing, Examination, Granting | 68191 | |
| Japan | Filing, Examination, Granting | 4081 | |
| South Korea | Filing, Examination, Granting | 6219 | |
| USA | Filing, Examination, Granting | 22440 |
Total:
105,607
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Compositions and methods useful to reduce expression of MAPT gene and for treatment of MAPT-associated diseases and conditions are provided. Provided are MAPT dsRNA agents, MAPT antisense polynucleotide agents, compositions comprising MAPT dsRNA agents, and compositions comprising MAPT antisense polynucleotide agents that can be used to reduce MAPT expression in cells and subjects.[French]
L'invention concerne des compositions et des procédés utiles pour réduire l'expression du gène MAPT et pour le traitement de maladies et d'affections associées à MAPT. L'invention concerne des agents ARNdb MAPT, des agents polynucléotidiques antisens MAPT, des compositions comprenant des agents ARNdb MAPT, et des compositions comprenant des agents polynucléotidiques antisens MAPT qui peuvent être utilisés pour réduire l'expression de MAPT dans des cellules et chez des sujets.