WO2025026381 - HETEROCYCLYLALKYNYL SUBSTITUTED AMIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
National phase entry:
Publication Number
WO/2025/026381
Publication Date
06.02.2025
International Application No.
PCT/CN2024/109119
International Filing Date
01.08.2024
Title **
[English]
HETEROCYCLYLALKYNYL SUBSTITUTED AMIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
[French]
DÉRIVÉ D'AMIDE SUBSTITUÉ PAR HÉTÉROCYCLYLALCYNYLE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
[Chinese]
杂环炔基取代的酰胺衍生物、其制备方法及其应用
Applicants **
CHENGDU CHIPSCREEN PHARMACEUTICAL LTD.
Inventors
LIU, Gang
XIA, Shanghua
DONG, Wenbo
LI, Jian
WANG, Tingting
XIE, Honglei
ZHANG, Ping
MAO, Xuhua
SHAN, Song
PAN, Desi
LU, Xianping
Priority Data
202310967490.1
02.08.2023
CN
202311824824.6
26.12.2023
CN
202410153280.3
02.02.2024
CN
202410605782.5
15.05.2024
CN
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2607 | |
| EPO | Filing, Examination, Granting | 15013 | |
| Japan | Filing, Examination, Granting | 2017 | |
| South Korea | Filing, Examination, Granting | 1877 | |
| USA | Filing, Examination, Granting | 5190 |
Total:
26,704
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
The present invention relates to a heterocyclylalkynyl substituted amide derivative as shown in a formula (I), and a preparation method therefor and the use thereof. The present invention also relates to a pharmaceutical composition comprising the compound as an active ingredient and the use of the compound or pharmaceutical composition for treating and/or preventing related diseases mediated by PRMT5.[French]
La présente invention concerne un dérivé d'amide substitué par hétérocyclylalcynyle tel que représenté dans la formule (I), son procédé de préparation et son utilisation. La présente invention concerne également une composition pharmaceutique comprenant le composé en tant que principe actif et l'utilisation du composé ou de la composition pharmaceutique pour le traitement et/ou la prévention de maladies associées médiées par PRMT5.[Chinese]
本发明涉及一种式(I)所示杂环炔基取代的酰胺衍生物、其制备方法及其应用。本发明还涉及包含所述化合物作为活性成分的药物组合物以及所述化合物或药物组合物用于治疗和/或预防由PRMT5介导的相关疾病的用途。