WO2024056044 - GENETICALLY MODIFIED NON-HUMAN ANIMALS AND METHODS FOR PRODUCING HEAVY-CHAIN ANTIBODIES
National phase entry:
Publication Number
WO/2024/056044
Publication Date
21.03.2024
International Application No.
PCT/CN2023/118958
International Filing Date
15.09.2023
Title **
[English]
GENETICALLY MODIFIED NON-HUMAN ANIMALS AND METHODS FOR PRODUCING HEAVY-CHAIN ANTIBODIES
[French]
ANIMAUX NON HUMAINS GÉNÉTIQUEMENT MODIFIÉS ET PROCÉDÉS DE PRODUCTION D'ANTICORPS À CHAÎNE LOURDE
Applicants **
BIOCYTOGEN PHARMACEUTICALS (BEIJING) CO., LTD.
Inventors
HU, Yiqing
ZHANG, Qi
ZHANG, Lijun
ZHANG, Yabo
ZHAO, Huizhen
YAO, Jiawei
SHEN, Yuelei
Priority Data
PCT/CN2022/119188
16.09.2022
CN
PCT/CN2022/136246
02.12.2022
CN
Application details
| Total Number of Claims/PCT | * |
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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| Translation |
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 4778 | |
| EPO | Filing, Examination, Granting | 77889 | |
| Japan | Filing, Examination, Granting | 4368 | |
| South Korea | Filing, Examination, Granting | 6677 | |
| USA | Filing, Examination, Granting | 31240 |
Total:
124,952
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
The present disclosure relates to genetically modified animals and methods for producing heavy-chain antibodies. In one aspect, the genetically modified non-human animal comprises a modified immunoglobulin heavy chain locus, wherein the modified immunoglobulin heavy chain locus comprises an IgG constant region gene, wherein the IgG constant region gene encodes an IgG heavy chain constant region lacking a CH1 domain, wherein the genetically modified non-human animal expresses a heavy-chain antibody. Also disclosed herein are anti-TFR1 antibodies, antigen-binding fragments, and the uses thereof.[French]
La présente invention concerne des animaux génétiquement modifiés et des procédés de production d'anticorps à chaîne lourde. Selon un aspect, l'animal non humain génétiquement modifié comprend un locus de chaîne lourde d'immunoglobuline modifiée, le locus de chaîne lourde d'immunoglobuline modifiée comprenant un gène de région constante d'IgG, le gène de région constante d'IgG codant pour une région constante de chaîne lourde d'IgG dépourvue de domaine CH1, l'animal non humain génétiquement modifié exprimant un anticorps à chaîne lourde. L'invention concerne également des anticorps anti-TFR1, des fragments de liaison à l'antigène et leurs utilisations.