WO2023169184 - BIOCATALYST AND METHOD FOR THE SYNTHESIS OF UBROGEPANT INTERMEDIATES
National phase entry:
Publication Number
WO/2023/169184
Publication Date
14.09.2023
International Application No.
PCT/CN2023/076973
International Filing Date
17.02.2023
Title **
[English]
BIOCATALYST AND METHOD FOR THE SYNTHESIS OF UBROGEPANT INTERMEDIATES
[French]
BIOCATALYSEUR ET PROCÉDÉ POUR LA SYNTHÈSE D'INTERMÉDIAIRES UBROGEPANTS
Applicants **
ENZYMASTER (NINGBO) BIO-ENGINEERING CO., LTD.
Inventors
CHEN, Haibin
HU, Hu
CAI, Baoqin
XU, Junpeng
LIU, Sitong
JIN, Luping
WU, Xinwei
CUI, Qinyan
ZHANG, Chengxiao
ZHU, Kailong
Priority Data
202210240991.5
10.03.2022
CN
Application details
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International Searching Authority |
CNIPA
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| Recordal of a Change of the Applicant's Name/Address |
Change of Applicant's Name and Address
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| Type of Assignment |
The Standard Agent's Assignment
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| Applicant's Legal Status |
Legal Entity
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| Entry into National Phase under |
Chapter I
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| Patent Delivery |
Send the Letters Patent by Courier
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 2154 | |
| EPO | Filing, Examination, Granting | 15825 | |
| Japan | Filing, Examination, Granting | 2362 | |
| South Korea | Filing, Examination, Granting | 2508 | |
| USA | Filing, Examination, Granting | 7340 |
Total:
30,189
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Provided are engineered transaminase polypeptides for the synthesis of Ubrogepant intermediates with high stereoselectivity, high catalytic activity and good stability. Also provided is a reaction process for the asymmetric synthesis of Ubrogepant intermediates using the transaminase polypeptide.[French]
La présente invention concerne des polypeptides transaminases modifiés pour la synthèse d'intermédiaires d'Ubrogepant présentant une stéréosélectivité élevée, une activité catalytique élevée et une bonne stabilité. La présente invention concerne également un procédé de réaction pour la synthèse asymétrique d'intermédiaires d'Ubrogepant à l'aide du polypeptide transaminase.