WO2023072170 - A METHOD FOR PROMOTING THE DIFFERENTIATION OF STEM CELLS INTO FUNCTIONALLY MATURE ISLET β CELLS AND USE THEREOF
National phase entry is expected:
Publication Number
WO/2023/072170
Publication Date
04.05.2023
International Application No.
PCT/CN2022/127805
International Filing Date
27.10.2022
Title **
[English]
A METHOD FOR PROMOTING THE DIFFERENTIATION OF STEM CELLS INTO FUNCTIONALLY MATURE ISLET β CELLS AND USE THEREOF
[French]
PROCÉDÉ POUR FAVORISER LA DIFFÉRENCIATION DES CELLULES SOUCHES EN CELLULES β D'ÎLOTS DE LANGERHANS FONCTIONNELLEMENT MATURES ET SON UTILISATION
Applicants **
SUNSHINE LAKE PHARMA CO., LTD.
Inventors
SONG, Yizhe
LI, Jingqiu
OU, Zhensheng
GUO, Leilei
TANG, Tingting
XING, Peiwen
LIU, Jing
ZHAO, Huifang
ZHANG, Shidu
YE, Qunrui
CHEN, Xiaofeng
LI, Wenjia
FENG, Shanshan
LI, Jing
Priority Data
202111264612.8
28.10.2021
CN
Application details
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International Searching Authority |
CNIPA
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Change of Applicant's Name and Address
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The Standard Agent's Assignment
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Legal Entity
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| Entry into National Phase under |
Chapter I
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Send the Letters Patent by Courier
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Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing, Examination, Granting | 1711 | |
| EPO | Filing, Examination, Granting | 10984 | |
| Japan | Filing, Examination, Granting | 2195 | |
| South Korea | Filing, Examination, Granting | 2164 | |
| USA | Filing, Examination, Granting | 5940 |
Total:
22,994
The term for entry into the National Phase has expired. This quotation is for informational purposes only
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Abstract[English]
Provided is a method for promoting the differentiation of pluripotent stem cells into functionally mature islet β cells. The method comprises: coculturing endocrine progenitor cells with medium containing an M3 muscarinic acetylcholine receptor agonist, so as to facilitate the differentiation of endocrine progenitor cells into islet β cells; wherein, the endocrine progenitor cells are generated from primitive gut tube cells through in vitro differentiation. During differentiation process from primitive gut tube cells to endocrine progenitor cells, the cells are not cocultured with medium containing the M3 muscarinic acetylcholine receptor agonist.[French]
La présente invention concerne un procédé permettant de favoriser la différenciation de cellules souches pluripotentes en cellules β d'îlots de Langerhans fonctionnellement matures. Le procédé comprend la coculture de cellules progénitrices endocrines avec un milieu contenant un agoniste du récepteur muscarinique de l'acétylcholine M3, afin de faciliter la différenciation des cellules progénitrices endocrines en cellules β d'îlots de Langerhans ; les cellules progénitrices endocrines étant générées à partir de cellules primitives du tube digestif par différenciation in vitro. Pendant le processus de différenciation des cellules primitives du tube digestif en cellules progénitrices endocrines, les cellules ne sont pas cocultivées avec un milieu contenant l'agoniste du récepteur muscarinique de l'acétylcholine M3.