WO2024189550 - PROCESS FOR THE PREPARATION OF ISAVUCONAZONIUM SULFATE AND ITS CRYSTALLINE FORMS
National phase entry is expected:
Publication Number
WO/2024/189550
Publication Date
19.09.2024
International Application No.
PCT/IB2024/052413
International Filing Date
13.03.2024
Title **
[English]
PROCESS FOR THE PREPARATION OF ISAVUCONAZONIUM SULFATE AND ITS CRYSTALLINE FORMS
[French]
PROCÉDÉ DE PRÉPARATION DE SULFATE D'ISAVUCONAZONIUM ET SES FORMES CRISTALLINES
Applicants **
APITORIA PHARMA PRIVATE LIMITED
Galaxy, Floors: 22-24, Plot No.1, Survey No.83/1, Hyderabad Knowledge City, Raidurg Panmaktha
Hyderabad 500032, IN
Inventors
THATAVARTHY, Rama Krishna
Apitoria Pharma Private Limited,
Galaxy, Floors: 22-24, Plot No.1, Survey No.83/1, Hyderabad Knowledge City,
Raidurg Panmaktha
Hyderabad 500 032, IN
PALAKURTHY, Nani Babu
Apitoria Pharma Private Limited, Galaxy, Floors: 22-24
Plot No.1, Survey No.83/1, Hyderabad Knowledge City,
Raidurg Panmaktha
Hyderabad 500 032, IN
KOSIREDDY, Ravanababu
Apitoria Pharma Private Limited, Galaxy, Floors: 22-24 Plot No.1, Survey No.83/1, Hyderabad Knowledge City, Raidurg Panmaktha
Hyderabad 500 032, IN
BATTHINI, Guruswamy
Apitoria Pharma Private Limited, Galaxy, Floors: 22-24 Plot No.1, Survey No.83/1, Hyderabad Knowledge City, Raidurg Panmaktha
Hyderabad 500 032, IN
MEENAKSHISUNDERAM, Sivakumaran
Apitoria Pharma Private Limited, Galaxy, Floors: 22-24 Plot No.1, Survey No.83/1, Hyderabad Knowledge City, Raidurg Panmaktha
Hyderabad 500 032, IN
MANDAD, Pratap Reddy
Apitoria Pharma Private Limited, Galaxy, Floors: 22-24 Plot No.1, Survey No.83/1, Hyderabad Knowledge City, Raidurg Panmaktha
Hyderabad 500 032, IN
MUPPALLA, Siva Rama Krishna
Apitoria Pharma Private Limited, Galaxy, Floors: 22-24 Plot No.1, Survey No.83/1, Hyderabad Knowledge City, Raidurg Panmaktha
Hyderabad 500 032, IN
ALI, Nasir
Apitoria Pharma Private Limited, Galaxy, Floors: 22-24 Plot No.1, Survey No.83/1, Hyderabad Knowledge City, Raidurg Panmaktha
Hyderabad 500 032, IN
NEELA, Praveen Kumar
Apitoria Pharma Private Limited, Galaxy, Floors: 22-24 Plot No.1, Survey No.83/1, Hyderabad Knowledge City, Raidurg Panmaktha
Hyderabad 500 032, IN
Priority Data
202341016815
13.03.2023
IN
202341025535
04.04.2023
IN
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| * | |
International Searching Authority |
IP India
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 1277 | |
| EPO | Filing, Examination | 7641 | |
| Japan | Filing | 531 | |
| South Korea | Filing | 607 | |
| USA | Filing, Examination | 6835 |
Total: 16891 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present invention provides novel, pure and stable crystalline forms of Isavuconazonium sulfate, a process for the preparation thereof and a pharmaceutical composition comprising crystalline forms of Isavuconazonium sulfate. The present invention further provides a process for the preparation of N-methyl-N-(3-[((N-tert-butoxycarbonyl-N-methylamino)acetoxy)methyl)pyridin-2-yl]carbamic acid 1-chloroethyl ester compound of Formula (I), and one pot process for the preparation of Isavuconazonium sulfate, which is obtained in high yield and purity without forming bi-products.[French]
La présente invention concerne de nouvelles formes cristallines pures et stables de sulfate d'isavuconazonium, un procédé pour leur préparation et une composition pharmaceutique comprenant des formes cristallines de sulfate d'isavuconazonium. La présente invention concerne en outre un procédé de préparation d'un composé 1-chloroéthyl ester d'acide N-méthyl-N- (3-[((N-tert-butoxycarbonyl-N-méthylamino)acétoxy)méthyl)pyridin-2-yl]carbamique de formule (I), et un procédé monopote pour la préparation de sulfate d'isavuconazonium, qui est obtenu avec un rendement et une pureté élevés sans former de biproduits.