WO2022144811 - MICELLAR NANOPARTICLES AND USES THEREOF
National phase entry:
Publication Number
WO/2022/144811
Publication Date
07.07.2022
International Application No.
PCT/IB2021/062446
International Filing Date
29.12.2021
Title **
[English]
MICELLAR NANOPARTICLES AND USES THEREOF
[French]
NANOPARTICULES MICELLAIRES ET LEURS UTILISATIONS
Applicants **
BIORCHESTRA CO., LTD.
2-F-216, Venture-dong, KRIBB, 125, Gwahak-ro
Yuseong-gu
Daejeon 34141, KR
Inventors
RYU, Jin-Hyeob
5-1501, 175, Dunsanbuk-ro
Seo-gu
Daejeon 35243, KR
LIM, Yu Na
105, 15, Gujeuk-ro, 52beon-gil
Yuseong-gu
Daejeon 34009, KR
MIN, Hyun Su
604-1303, 32-41, Sodam-dong
Sejong-si
Sejong 30150, KR
KOH, Han Seok
1F-116 and 2F-216 Venture-dong
KRIBB, 125, Gwanhak-ro
Yuseong-gu
Daejeon 34141, KR
KIM, Dae Hoon
1F-116 and 2F-216, Venture-dong
KRIBB, 125, Gwanhak-ro
Yuseong-gu
Daejeon 34141, KR
CHO, Hyun-Jeong
1F-116 and 2F-216, Venture-dong
KRIBB, 125, Gwanhak-ro
Yuseong-gu
Daejeon 34141, KR
Priority Data
63/199,471
30.12.2020
US
63/260,782
31.08.2021
US
63/260,989
08.09.2021
US
Application details
| Total Number of Claims/PCT | * |
| Number of Independent Claims | * |
| Number of Priorities | * |
| Number of Multi-Dependent Claims | * |
| Number of Drawings | * |
| Pages for Publication | * |
| Number of Pages with Drawings | * |
| Pages of Specification | * |
| * | |
| * | |
International Searching Authority |
MOIP
* |
| Applicant's Legal Status |
Legal Entity
* |
| * | |
| * | |
| * | |
| * | |
| Entry into National Phase under |
Chapter I
* |
| Translation |
|
Recalculate
* The data is based on automatic recognition. Please verify and amend if necessary.
** IP-Coster compiles data from publicly available sources. If this data includes your personal information, you can contact us to request its removal.
Quotation for National Phase entry
| Country | Stages | Total | |
|---|---|---|---|
| China | Filing | 4813 | |
| EPO | Filing, Examination | 68546 | |
| Japan | Filing | 590 | |
| South Korea | Filing | 640 | |
| USA | Filing, Examination | 26810 |
Total: 101399 USD
The term for entry into the National Phase has expired. This quotation is for informational purposes only
Abstract[English]
The present disclosure includes cationic carrier units comprising (i) a water-soluble polymer, (ii) a positively charged carrier, (iii) a hydrophobic moiety, and (iv) a crosslinking moiety, wherein when the cationic carrier unit is mixed with an anionic payload (e.g., an antisense oligonucleotide) that electrostatically interacts with the cationic carrier unit, the resulting composition self-organizes into a micelle encapsulating the anionic payload in its core. The cationic carrier units can also comprise a tissue specific targeting moiety, which would be displayed on the surface of the micelle. The disclosure also includes micelles comprising the cationic carrier units of the disclosure, methods of manufacture of cationic carrier units and micelles, pharmaceutical compositions comprising the micelles, and also methods of treating diseases or conditions comprising administering the micelles to a subject in need thereof.[French]
La présente divulgation comprend des unités de support cationiques constituées (i) d'un polymère hydrosoluble, (ii) d'un support chargé positivement, (iii) d'un fragment hydrophobe et (iv) d'un fragment de réticulation, la composition résultante se réorganisant d'elle-même en une micelle encapsulant la charge utile anionique dans son noyau lorsque l'unité de support cationique est mélangée avec une charge utile anionique (p. ex. un oligonucléotide antisens) qui interagit électrostatiquement avec l'unité de support cationique. Les unités de support cationiques peuvent également comprendre une fraction de ciblage spécifique du tissu, qui sera affichée sur la surface de la micelle. La divulgation comprend également des micelles comprenant les unités de support cationiques de la divulgation, des procédés de fabrication d'unités de support cationiques et de micelles, des compositions pharmaceutiques comprenant les micelles, et également des procédés de traitement de maladies ou d'états pathologiques comprenant l'administration des micelles à un sujet qui en a besoin.